publication . Doctoral thesis . 1997

Molecular basis and pharmacological implications of Alzheimer amyloid ß-peptide fibril formation,

  • Published: 26 Dec 1997
  • Country: Sweden
Abstract
Alzheimer's disease is a progressive neurodegenerative disease, mostly affectingelderly. The invariable deposition of protease-resistant fibrils of Alzheimer amyloidß-peptide (Aß) in the parenchyma and blood vessels of the brain is a centralevent. The aim of this study was to investigate whether Aß develops proteaseresistance upon polymerization and whether Aß may be generated through non specificproteolysis of a polymerized precursor, to identify Aß-Aß binding and fibrilforming sequences in Aß and define the molecular basis of Aß polymerization,and to find inhibitors of fibril formation. To investigate if Aß fibril formation is sufficient to acquire protease re...
Subjects
Medical Subject Headings: macromolecular substances
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