publication . Doctoral thesis . 1998

Molecular basis and pharmacological implications of Alzheimer amyloid ß-peptide fibril formation,

Tjernberg, Lars;
English
  • Published: 01 Jan 1998
  • Publisher: Karolinska Institutet, false
Abstract
Alzheimer's disease is a progressive neurodegenerative disease, mostly affectingelderly. The invariable deposition of protease-resistant fibrils of Alzheimer amyloidß-peptide (Aß) in the parenchyma and blood vessels of the brain is a centralevent. The aim of this study was to investigate whether Aß develops proteaseresistance upon polymerization and whether Aß may be generated through non specificproteolysis of a polymerized precursor, to identify Aß-Aß binding and fibrilforming sequences in Aß and define the molecular basis of Aß polymerization,and to find inhibitors of fibril formation. To investigate if Aß fibril formation is suffi...
Subjects
mesheuropmc: macromolecular substances
free text keywords: MEDICIN OCH HÄLSOVETENSKAP, Alzheimer's disease, amyloid, fibrils, inhibitor, protease resistance,electron microscopy, fluorescence correlation spectroscopy., MEDICAL AND HEALTH SCIENCES
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