publication . Doctoral thesis . 2001

Human truncated thioredoxin (Trx80) as a novel mitogenic cytokine for white blood cells

  • Published: 27 Nov 2001
  • Country: Sweden
Abstract
Thioredoxin (Trx) is a 12 kDa protein present in all species with a well-conserved active site sequence comprising -Cys-Gly-Pro-Cys-, which catalyzes oxido-reductase reactions. Trx regulates the activity of transcription factors and intracellular signalling pathways, and secreted Trx is a co-cytokine with several interleukins. In addition to full-length Trx a 10 kDa C-terminally truncated form of the protein is produced mainly by monocytes. This protein has unique eosinophilic cytotoxicity enhancing effects, although it does not possess the classical oxido-reductase activity of Trx. We have cloned, overexpressed and purified truncated Trx comprising the 80 or 84...
Subjects
Medical Subject Headings: animal structures
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