publication . Doctoral thesis . 1999

Cell transplantation and immunoisolation : studies on a macroencapsulation device

  • Published: 26 Nov 1999
  • Country: Sweden
Abstract
Encapsulation of cellular grafts in semipermeable membranes may provide a way to protect the graft from immune attack without the need for pharmacological immunosuppression. In this thesis, the use of immunoisolating devices consisting of a bilaminar PTFE membrane was evaluated. Previous experimental studies indicate that these devices can protect cellular allografts from rejection. This thesis aims at improving our understanding of physiological factors influencing graft survival. In the first study, the use of macroencapsulation for protection of human parathyroid allograft was evaluated. The following studies focused on the physiological milieu in the device ...
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