publication . Doctoral thesis . 2013

ON THE ROLE OF PERIOD-2 IN THE CIRCADIAN AND HOMEOSTATIC REGULATION OF SLEEP

La Spada, F.;
Open Access English
  • Published: 01 Nov 2013
  • Publisher: Université de Lausanne, Faculté de biologie et médecine
Abstract
Humans spend one third of their life sleeping, then we could raise the basic question: Why do we sleep? Despite the fact that we still don't fully understand its function, we made much progress in understanding at different levels how sleep is regulated. One model suggests that sleep is regulated by two processes: a homeostatic process that tracks the need for sleep and by a circadian rhythm that determines the preferred time-of-day sleep occurs. At the molecular level circadian rhythms are a property of interlocking transcriptional regula-tors referred to as clock genes. The heterodimeric transcription factors BMAL1::CLOCK/NPAS2 drive the transcription of many ...
Subjects
Medical Subject Headings: endocrine system
free text keywords: sleep homeostasis; circadian; period-2; sleep deprivation; DNA-binding
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