publication . Article . 2017

Genome of the carbapenemase-producing clinical isolate Elizabethkingia miricola EM_CHUV and comparative genomics with Elizabethkingia meningoseptica and Elizabethkingia anophelis: evidence for intrinsic multidrug resistance trait of emerging pathogens.

Onya Opota; Seydina M. Diene; Claire Bertelli; Guy Prod'hom; Philippe Eckert; Gilbert Greub;
Open Access English
  • Published: 01 Jan 2017
Abstract
Abstract Elizabethkingia miricola is a Gram-negative non-fermenting rod emerging as a life-threatening human pathogen. The multidrug-resistant (MDR) carbapenemase-producing clinical isolate E. miricola EM_CHUV was recovered in the setting of severe nosocomial pneumonia. In this study, the genome of E. miricola EM_CHUV was sequenced and a functional analysis was performed, including a comparative genomic study with Elizabethkingia meningoseptica and Elizabethkingia anophelis . The resistome of EM_CHUV revealed the presence of a high number of resistance genes, including the presence of the bla GOB-13 and bla B-9 carbapenemase-encoding genes. Twelve mobility genes...
Subjects
free text keywords: Adult; Aged, 80 and over; Child, Preschool; Cross Infection/microbiology; Drug Resistance, Multiple, Bacterial; Female; Flavobacteriaceae/enzymology; Flavobacteriaceae/genetics; Flavobacteriaceae/isolation & purification; Flavobacteriaceae Infections/microbiology; Genes, Bacterial; Genome, Bacterial; Humans; Male; Middle Aged; Pneumonia, Bacterial/microbiology; Sequence Analysis, DNA, Comparative genomics, Prophage, Genome, Gene, Microbiology, Biology, Genetics, Elizabethkingia miricola, Resistome, Elizabethkingia meningoseptica, biology.organism_classification, Elizabethkingia anophelis, medicine.disease_cause, medicine
Powered by OpenAIRE Open Research Graph
Any information missing or wrong?Report an Issue
publication . Article . 2017

Genome of the carbapenemase-producing clinical isolate Elizabethkingia miricola EM_CHUV and comparative genomics with Elizabethkingia meningoseptica and Elizabethkingia anophelis: evidence for intrinsic multidrug resistance trait of emerging pathogens.

Onya Opota; Seydina M. Diene; Claire Bertelli; Guy Prod'hom; Philippe Eckert; Gilbert Greub;