Ammonium-Induced Impairment of Axonal Growth Is Prevented through Glial Creatine

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Braissant, O.; Henry, H.; Villard, A.M.; Zurich, M.G.; Loup, M.; Eilers, B.; Parlascino, G.; Matter, E.; Boulat, O.; Honegger, P.; Bachmann, C.;
  • Publisher: Society for Neuroscience
  • Journal: eissn: 1529-2401
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1523/JNEUROSCI.22-22-09810.2002, pmc: PMC6757846
  • Subject: Adenosine Diphosphate/metabolism; Adenosine Monophosphate/metabolism; Adenosine Triphosphate/metabolism; Ammonium Chloride/toxicity; Animals; Axons/drug effects; Axons/metabolism; Axons/physiology; Cell Differentiation/physiology; Cell Division/drug effects; Cells, Cultured; Choline O-Acetyltransferase/biosynthesis; Coculture Techniques; Creatine/metabolism; Creatine/pharmacology; Dose-Response Relationship, Drug; GAP-43 Protein/biosynthesis; Glucose/pharmacokinetics; Immunohistochemistry; Intracellular Fluid/metabolism; Lactic Acid/metabolism; Neurofilament Proteins/biosynthesis; Neuroglia/cytology; Neuroglia/metabolism; Neurons/cytology; Neurons/drug effects; Neurons/metabolism; Phosphocreatine/metabolism; Quaternary Ammonium Compounds/pharmacokinetics; Rats; Telencephalon/cytology; Telencephalon/embryology | ARTICLE

Hyperammonemia in neonates and infants affects brain development and causes mental retardation. We report that ammonium impaired cholinergic axonal growth and altered localization and phosphorylation of intermediate neurofilament protein in rat reaggregated brain cell p... View more
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