publication . Article . Other literature type . 2005

Distinct Roles for Different Homer1 Isoforms in Behaviors and Associated Prefrontal Cortex Function

Lominac, K.; Oleson, E.; Pava, M.; Klugmann, M.; Schwarz, M.; Seeburg, P.; During, M.; Worley, P.; Kalivas, P.; Szumlinski, K.;
Open Access
  • Published: 14 Dec 2005 Journal: Journal of Neuroscience, volume 25, pages 11,586-11,594 (issn: 0270-6474, eissn: 1529-2401, Copyright policy)
  • Publisher: Society for Neuroscience
Abstract
Homer1 mutant mice exhibit behavioral and neurochemical abnormalities that are consistent with an animal model of schizophrenia. Because the Homer1 gene encodes both immediate early gene (IEG) and constitutively expressed (CC) gene products, we used the local infusion of adeno-associated viral vectors carrying different Homer1 transcriptional variants into the prefrontal cortex (PFC) to distinguish between the roles for IEG and CC Homer1 isoforms in the "schizophrenia-like" phenotype of Homer1 mutant mice. PFC overexpression of the IEG Homer1 isoform Homer1a reversed the genotypic differences in behavioral adaptation to repeated stress, whereas overexpression of...
Subjects
free text keywords: General Neuroscience, Neurochemical, Basal (phylogenetics), Endocrinology, medicine.medical_specialty, medicine, Prefrontal cortex, HOMER1, Gene isoform, Immediate early gene, Mutant, Internal medicine, Biology, Glutamate receptor, Behavioral/Systems/Cognitive
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