publication . Article . 2002

Fine mapping of the chromosome 2p12-16 dyslexia susceptibility locus: quantitative association analysis and positional candidate genes SEMA4F and OTX1

Clyde Francks; Simon E. Fisher; Richard K. Olson; Bruce F. Pennington; Shelley D. Smith; John C. DeFries; Anthony P. Monaco;
  • Published: 01 Jan 2002
  • Publisher: Ovid Technologies (Wolters Kluwer Health)
Abstract
A locus on chromosome 2p12-16 has been implicated in dyslexia susceptibility by two independent linkage studies, including our own study of 119 nuclear twin-based families, each with at least one reading-disabled child. Nonetheless, no variant of any gene has been reported to show association with dyslexia, and no consistent clinical evidence exists to identify candidate genes with any strong a priori logic. We used 21 microsatellite markers spanning 2p12-16 to refine our 1-LOD unit linkage support interval to 12cM between D2S337 and D2S286. Then, in quantitative association analysis, two microsatellites yielded P values<0.05 across a range of reading-related me...
Subjects
free text keywords: Genetics(clinical), Genetics, Biological Psychiatry, Psychiatry and Mental health, Quantitative trait locus, Locus (genetics), Linkage disequilibrium, Genetic association, Association mapping, Psychology, Dyslexia, medicine.disease, medicine, Candidate gene, Genetic linkage
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publication . Article . 2002

Fine mapping of the chromosome 2p12-16 dyslexia susceptibility locus: quantitative association analysis and positional candidate genes SEMA4F and OTX1

Clyde Francks; Simon E. Fisher; Richard K. Olson; Bruce F. Pennington; Shelley D. Smith; John C. DeFries; Anthony P. Monaco;