publication . Article . Other literature type . 2016

Chitosan/alginate based multilayers to control drug release from ophthalmic lens.

Silva, Diana; Pinto, Luís F.V.; Bozukova, Dimitriya; Santos, Luís F.; Serro, Ana Paula; Saramago, Benilde;
Open Access English
  • Published: 01 Nov 2016
  • Publisher: Elsevier
In this study we investigated the possibility of using layer-by-layer deposition, based in natural polymers (chitosan and alginate), to control the release of different ophthalmic drugs from three types of lens materials: a silicone-based hydrogel recently proposed by our group as drug releasing soft contact lens (SCL) material and two commercially available materials: CI26Y for intraocular lens (IOLs) and Definitive 50 for SCLs. The optimised coating, consisting in one double layer of (alginate – CaCl2)/(chitosan + glyoxal) topped with a final alginate-CaCl2 layer to avoid chitosan degradation by tear fluid proteins, proved to have excellent features to control...
free text keywords: Controlled drug release, Ophthalmic lens, Layer-by-layer coatings, Alginate, Chitosan, Biocompatibility, Intraocular lens, medicine.medical_treatment, medicine, Coating, engineering.material, engineering, Controlled release, Biomedical engineering, Nanotechnology, Chemistry, Chromatography, chemistry.chemical_compound, Lens (optics), law.invention, law, Contact lens, Silicone
Funded by
FCT| UID/QUI/00100/2013
Centro de Química Estrutural
  • Funder: Fundação para a Ciência e a Tecnologia, I.P. (FCT)
  • Project Code: 147216
  • Funding stream: 5876
FCT| M-ERA.NET/0005/2012
Surface modifications to control drug release from therapeutic ophthalmic lenses
  • Funder: Fundação para a Ciência e a Tecnologia, I.P. (FCT)
  • Project Code: 137199
  • Funding stream: 3599-PPCDT
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