publication . Article . Other literature type . 2016

Chitosan/alginate based multilayers to control drug release from ophthalmic lens.

Silva, Diana; Pinto, Luís F.V.; Bozukova, Dimitriya; Santos, Luís F.; Serro, Ana Paula; Saramago, Benilde;
Open Access English
  • Published: 01 Nov 2016
  • Publisher: Elsevier
Abstract
In this study we investigated the possibility of using layer-by-layer deposition, based in natural polymers (chitosan and alginate), to control the release of different ophthalmic drugs from three types of lens materials: a silicone-based hydrogel recently proposed by our group as drug releasing soft contact lens (SCL) material and two commercially available materials: CI26Y for intraocular lens (IOLs) and Definitive 50 for SCLs. The optimised coating, consisting in one double layer of (alginate – CaCl2)/(chitosan + glyoxal) topped with a final alginate-CaCl2 layer to avoid chitosan degradation by tear fluid proteins, proved to have excellent features to control...
Subjects
free text keywords: Controlled drug release, Ophthalmic lens, Layer-by-layer coatings, Alginate, Chitosan, Biocompatibility, Intraocular lens, medicine.medical_treatment, medicine, Coating, engineering.material, engineering, Controlled release, Biomedical engineering, Nanotechnology, Chemistry, Chromatography, chemistry.chemical_compound, Lens (optics), law.invention, law, Contact lens, Silicone
Funded by
FCT| UID/QUI/00100/2013
Project
UID/QUI/00100/2013
Centro de Química Estrutural
  • Funder: Fundação para a Ciência e a Tecnologia, I.P. (FCT)
  • Project Code: 147216
  • Funding stream: 5876
,
FCT| M-ERA.NET/0005/2012
Project
M-ERA.NET/0005/2012
Surface modifications to control drug release from therapeutic ophthalmic lenses
  • Funder: Fundação para a Ciência e a Tecnologia, I.P. (FCT)
  • Project Code: 137199
  • Funding stream: 3599-PPCDT
20 references, page 1 of 2

[1] [2] [3] [4] [5] [15] C. González-Chomón, A. Concheiro, C. Alvarez-Lorenzo, Soft contact lenses for controlled ocular delivery: 50 years in the making, Ther. Deliv. 4 (2013) 1141- 1161. [OpenAIRE]

P.W.J. Morrison, V. V. Khutoryanskiy, Advances in ophthalmic drug delivery, Ther. Deliv. 5 (2014) 1297-1315. [OpenAIRE]

A. ElShaerl, B. Ghatoral, S. Mustafal, R.G. Alany, Contact lenses as drug reservoirs & delivery systems: the successes & challenges, Ther. Deliv. 5 (2014) 1085-1100.

C. González-Chomón, A. Concheiro, C. Alvarez-Lorenzo, Drug-Eluting Intraocular Lenses, Materials (Basel). 4 (2011) 1927-1940. [OpenAIRE]

Y. Masmoudia, L.B. Azzouka, O. Forzanob, J.M. Andreb, E. Badensa, Supercritical impregnation of intraocular lenses, J. Supercrit. Fluids. 60 (2011) 98-105.

A. Shukla, R.C. Fuller, P.T. Hammond, Design of multi-drug release coatings targeting infection and inflammation, J. Control. Release. 155 (2011) 159-166.

C. Lokendrakumar, A. Chauhan, Extended delivery of an anionic drug by contact lens loaded with a cationic surfactant, Biomaterials. 34 (2013) 2814-2821. [OpenAIRE]

Ophthalmol. Vis. Sci. 45 (2004) 2342-2347.

H. Lu, Z. Chen, X. Yang, L. Cen, X. Zhang, P. Gao, Layer-by-layer selfassembly of minocycline-loaded chitosan/alginate multilayer on titanium substrates to inhibit biofilm formation, J. Dent. 42 (2014) 1464-1472.

Polym. 69 (2007) 336-343.

Y. Yang, S. Wang, Y. Wang, X. Wang, Q. Wang, M. Chen, Advances in selfassembled chitosan nanomaterials for drug delivery, Biotechnol. Adv. 32 (2014) 1301-1316.

[36] [32] P. Paradiso, R. Galante, L. Santos, A.P. Alves de Matos, R. Colaço, A.P. Serro, et al., Comparison of two hydrogel formulations for drug release in ophthalmic lenses, J Biomed Mater Res B. 102 (2014) 1170-1180.

[34] E. Vasil'eva, S. Kidalov, V. Sokolov, G. Klimov, J. Puguang, Properties of copper-detonation nanodiamond composites obtained by spray drying, Tech. Phys. Lett. 39 (2013) 137-139. doi:10.1134/S1063785013010410.

[35] S. Lemaire, P.M. Tulkens, F. Van Bambeke, Contrasting Effects of Acidic pH on the Extracellular and Intracellular Activities of the Anti-Gram-Positive Fluoroquinolones Moxifloxacin and Delafloxacin against Staphylococcus aureus, Antimicrob. Agents Chemother. 55 (2011) 649-658.

M. Elder, J.G. Dart, S. Kilvington, D.V. Seal, J. Hay, C.M. Kirkness, Chemotherapy for acanthamoeba keratitis, Lancet. 345 (1995) 791-793. [OpenAIRE]

20 references, page 1 of 2
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