publication . Article . 2005

Physicochemical and biological studies of a new erythromycin derivate - erythromycin folate

Manna, P.K.; Kumaran, V.; Mohanta, G.P.;
Open Access English
  • Published: 01 Jan 2005
  • Publisher: Universidad de Granada, Facultad de Farmacia
  • Country: Spain
Abstract
A new derivative of erythromycin, Erythromycin folate was prepared and its physicochemical and biological properties were evaluated. The derivative has good solubility in methanol, ethanol and propylene glycol. The partition coefficient values of 1.12 and 1.10 in chloroform/water and octanol/water systems respectively indicate that the derivative will probably distribute well in vivo. The in vitro potency of the derivative, 716 μg/mg, is higher than the existing derivatives like erythromycin estolate, erythromycin stearate, erythromycin ethyl succinate, erythromycin gluceptate, and erythromycin lactobionate. The in vitro Minimum Inhibitory Concentrations are les...
Subjects
free text keywords: Folato de eritromicina, Erythromycin folate, Actividad antimicrobiana in vitro, In vitro antimicrobial activity, Concentración sérica in vivo, In vivo serum concentration, Parámetros farmacocinético, Pharmacokinetic parameters
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