publication . Article . 2006

Synthesis and evaluation of dual acting esters of aspirin and ketorolac

Halen, P.K.; Yadav, M.R.; Chagti, K.K.; Reshmi, C.S.; Giridhar, R.;
Open Access Spanish; Castilian
  • Published: 01 Jan 2006
  • Publisher: Universidad de Granada, Facultad de Farmacia
  • Country: Spain
Abstract
Se sintetizaron y evaluaron cinco ésteres aminoetílicos N,N-disustituidos derivados del ketorolaco y la aspirina para eliminar su toxicidad gástrica. Se diseñaron especialmente ésteres intactos para satisfacer el requisito estructural de disponer de una actividad anticolinérgica antes de la separación. Además de bloquear el grupo carboxilato ácido mediante esterifi cación, esta actividad se incorporó a los ésteres sintetizados, con el benefi cio adicional esperado de la reducción de la secreción de ácido gástrico y la consecuente eliminación de la irritación local mediante un mecanismo dual. En este estudio se describen la síntesis, la cinética de la hidrólisis ...
Subjects
free text keywords: Aspirina, Aspirin, Ketorolaco, Ketorolac, Irritación local, Local irritation
Related Organizations

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