Cross-Reactivity of Anthrax and C2 Toxin: Protective Antigen Promotes the Uptake of Botulinum C2I Toxin into Human Endothelial Cells

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Kronhardt , Angelika; Rolando , Roland; Beitzinger , Christoph; Stefani , Caroline; Leuber , Michael; Flatau , Gilles; Popoff , Michel; Benz , Roland; Lemichez , Emmanuel;
  • Publisher: Public Library of Science
  • Related identifiers: doi: 10.1371/journal.pone.0023133
  • Subject: Actins | Intoxication | Cell binding | ADP-ribosylation | Enzyme structure | Lipid bilayer | Toxins | Anthrax | [ SDV.TOX ] Life Sciences [q-bio]/Toxicology

International audience; Binary toxins are among the most potent bacterial protein toxins performing a cooperative mode of translocation and exhibit fatal enzymatic activities in eukaryotic cells. Anthrax and C2 toxin are the most prominent examples for the AB(7/8) type ... View more
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