publication . Other literature type . 2008

Pharmacogenetic Variation at CYP2D6, CYP2C9, and CYP2C19 : Population Genetic and Forensic Aspects

Sistonen, Johanna;
Open Access English
  • Published: 21 Nov 2008
  • Publisher: Helsingin yliopisto
  • Country: Finland
Abstract
Pharmacogenetics deals with genetically determined variation in drug response. In this context, three phase I drug-metabolizing enzymes, CYP2D6, CYP2C9, and CYP2C19, have a central role, affecting the metabolism of about 20-30% of clinically used drugs. Since genes coding for these enzymes in human populations exhibit high genetic polymorphism, they are of major pharmacogenetic importance. The aims of this study were to develop new genotyping methods for CYP2D6, CYP2C9, and CYP2C19 that would cover the most important genetic variants altering the enzyme activity, and, for the first time, to describe the distribution of genetic variation at these loci on global a...
Subjects
free text keywords: farmakogenetiikka
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