publication . Other literature type . 2010

Molecular Pathways of Disturbed Sleep and Depression : Studies on Adenosine and Gene Expression Patterns

Gass, Natalia;
Open Access English
  • Published: 10 Dec 2010
  • Publisher: Helsingin yliopisto
  • Country: Finland
Abstract
Background: Adenosine is a potent sleep-promoting substance, and one of its targets is the basal forebrain. Fairly little is known about its mechanism of action in the basal forebrain and about the receptor subtype mediating its regulating effects on sleep homeostasis. Homeostatic deficiency might be one of the causes of the profoundly disturbed sleep pattern in major depressive disorder, which could explain the reduced amounts of delta-activity-rich stages 3 and 4. Since major depression has a relatively high heritability, and on the other hand adenosine regulates sleep homeostasis and might also be involved in mood modulation, adenosine-related genes should be...
Subjects
free text keywords: neurotiede
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