publication . Article . 2012

Conformational Control of Energy Transfer: A Mechanism for Biocompatible Nanocrystal-Based Sensors

Euan Kay;
Open Access
  • Published: 06 Dec 2012 Journal: Angewandte Chemie, volume 125, pages 1,203-1,207 (issn: 0044-8249, Copyright policy)
  • Publisher: Wiley
  • Country: United States
Abstract
Fold-up fluorophore: A new paradigm for designing self-referencing fluorescent nanosensors is demonstrated by interfacing a pH-triggered molecular conformational switch with quantum dots. Analytedependent, large-amplitude conformational motion controls the distance between the nanocrystal energy donor and an organic FRET acceptor. The result is a fluorescence signal capable of reporting pH values from individual endosomes in living cells.
Subjects
free text keywords: biosensors, fluorescent probes, quantum dots, molecular devices, molecular machines, General Medicine, General Chemistry, Catalysis
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