publication . Doctoral thesis . 2016

Exploring Biomolecular Interactions Through Single-Molecule Force Spectroscopy and Computational Simulation

Yang, Darren;
Open Access English
  • Published: 01 Jan 2016
  • Publisher: Harvard University
  • Country: United States
Abstract
Molecular interactions between cellular components such as proteins and nucleic acids govern the fundamental processes of living systems. Technological advancements in the past decade have allowed the characterization of these molecular interactions at the single-molecule level with high temporal and spatial resolution. Simultaneously, progress in computer simulation has enabled theoretical research at the atomistic level, assisting in the interpretation of experimental results. This thesis combines single-molecule force spectroscopy and simulation to explore inter- and intra-molecular interactions. Specifically, we investigate the interaction between RecA and D...
Subjects
free text keywords: Biophysics, General, Biology, Molecular, Physics, General
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