publication . Other literature type . Article . 2014

Epigenetic modifications: basic mechanisms and role in cardiovascular disease (2013 Grover Conference series)

Joseph Loscalzo; Diane E. Handy;
  • Published: 01 Jun 2014
  • Publisher: SAGE Publications
  • Country: United States
Abstract
Abstract Epigenetics refers to heritable traits that are not a consequence of DNA sequence. Three classes of epigenetic regulation exist: DNA methylation, histone modification, and noncoding RNA action. In the cardiovascular system, epigenetic regulation affects development, differentiation, and disease propensity or expression. Defining the determinants of epigenetic regulation offers opportunities for novel strategies for disease prevention and treatment.
Subjects
free text keywords: methylation, histone, noncoding RNAs, atherosclerosis, homocysteine, pulmonary hypertension, Review Article, Pulmonary and Respiratory Medicine, DNA sequencing, Disease prevention, DNA methylation, Disease, Epigenetics, Genetics, Non-coding RNA, Biology, biology.protein
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