publication . Article . Other literature type . 2018

Use of ‘eradication’ in HIV cure-related research: a public health debate

Dubé, Karine; Luter, Stuart; Lesnar, Breanne; Newton, Luke; Galea, Jerome; Brown, Brandon; Gianella, Sara;
Open Access English
  • Published: 13 Feb 2018
  • Publisher: eScholarship, University of California
  • Country: United States
Abstract
Abstract Background The landscape of Human Immunodeficiency Virus (HIV) research has changed drastically over the past three decades. With the remarkable success of antiretroviral treatment (ART) in decreasing AIDS-related mortality, some researchers have shifted their HIV research focus from treatment to cure research. The HIV cure research community often uses the term eradication to describe the science, and talks about eradicating the virus from the body. In public discourse, the term eradication could be conflated with disease eradication at the population level. In this paper, we call for a reframing of HIV cure research as control, as it is a more accurat...
Subjects
Medical Subject Headings: virus diseasesmacromolecular substances
free text keywords: *Biomedical Research Disease Eradication HIV Infections/*prevention & control Humans Public Health *Terminology as Topic *Eradication *HIV cure *Public health *Terminology, Public Health and Health Services, Public Health, Humans, HIV Infections, Biomedical Research, Terminology as Topic, Disease Eradication, Infectious Diseases, HIV/AIDS, Dental/Oral and Craniofacial Disease, Infection, HIV cure, Eradication, Terminology, Public aspects of medicine, RA1-1270, Debate, Public Health, Environmental and Occupational Health, HIV vaccine, Intensive care medicine, medicine.medical_specialty, medicine, business.industry, business, Cognitive reframing, Human immunodeficiency, Epidemiology, Population, education.field_of_study, education, Biostatistics, Environmental health
54 references, page 1 of 4

1.UNAIDS. UNAIDS Data 2017 [Internet]. 2017. Available: http://www.unaids.org/sites/default/files/media_asset/20170720_Data_book_2017_en.pdf

Marcus, JL, Chao, CR, Leyden, WA, Xu, L, Quesenberry, CP, Klein, DB. Narrowing the gap in life expectancy between HIV-infected and HIV-uninfected individuals with access to Care. JAIDS. 2016; 73: 39-46 [OpenAIRE] [PubMed]

Chun, TW, Stuyver, L, Mizell, SB, Ehler, LA, Mican, JA, Baseler, M. Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy. Proc Natl Acad Sci U S A. 1997; 94: 13193-13197 [OpenAIRE] [PubMed] [DOI]

4.TAG. Research Toward a Cure Trials [Internet]. 2017. Available: http://www.treatmentactiongroup.org/cure/trials

5.FDA. Backgrounder for FDA’s HIV Patient-Focused Drug Development and HIV Cure Research Public Meeting [Internet]. 2013. Available: http://www.fda.gov/downloads/ForIndustry/UserFees/PrescriptionDrugUserFee/UCM354549.pdf

6.Fauci A. Sustained ART-free HIV remission: opportunities and obstacles. International AIDS Society 2017. Available: http://programme.ias2017.org/Search/Search?search=Fauci

Allers, K, Hütter, G, Hofmann, J, Loddenkemper, C, Rieger, K, Thiel, E. Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation. Blood. 2011; 117: 2791-2799 [OpenAIRE] [PubMed] [DOI]

8.Dowdle W. Principles of Disease Elimination and Eradication. In: MMWR Morb Mortal Wkly Rep [Internet]. 1999 [cited 18 Sep 2017] pp. 23–7. Available: https://www.cdc.gov/mmwr/preview/mmwrhtml/su48a7.htm

9.CDC. Recommendations of the International Task Force for Disease Eradication. MMWR. 1993;42: 46 pages. Available: https://www.cdc.gov/mmwr/PDF/rr/rr4216.pdf

Spivak, AM, Planelles, V. HIV-1 eradication: early trials (and tribulations). Trends Mol Med Elsevier Ltd. 2016; 22: 10-27 [OpenAIRE] [DOI]

Margolis, DM. Eradication Therapies for HIV Infection: Time to Begin Again. AIDS Res Hum Retroviruses. 2011; 27 (4): 347-353 [OpenAIRE] [PubMed] [DOI]

Archin, N, Sung, J, Garrido, C, Soriano-Sarabia, N, Eradicating, MD. HIV-1 infection: seeking to clear a persistent pathogen. Nat Rev Microbiol. 2014; 12: 750-764 [OpenAIRE] [PubMed] [DOI]

Martin, AR, Siliciano, RF. Progress Toward HIV eradication: case reports, current efforts, and the challenges associated with cure. Annu Rev Med. 2016; 67: 1-14 [OpenAIRE] [PubMed] [DOI]

Zhang, J, Crumpacker, C. Eradication of HIV and cure of AIDS, now and how?. Front Immunol. 2013; 4: 337 [OpenAIRE] [PubMed] [DOI]

Tateishi, H, Monde, K, Anraku, K, Koga, R, Hayashi, Y. A Clue to Unprecedented Strategy to HIV Eradication: “Lock-in and apoptosis.” Sci Rep. Springer US. 2017; 7: 8957 [OpenAIRE]

54 references, page 1 of 4
Abstract
Abstract Background The landscape of Human Immunodeficiency Virus (HIV) research has changed drastically over the past three decades. With the remarkable success of antiretroviral treatment (ART) in decreasing AIDS-related mortality, some researchers have shifted their HIV research focus from treatment to cure research. The HIV cure research community often uses the term eradication to describe the science, and talks about eradicating the virus from the body. In public discourse, the term eradication could be conflated with disease eradication at the population level. In this paper, we call for a reframing of HIV cure research as control, as it is a more accurat...
Subjects
Medical Subject Headings: virus diseasesmacromolecular substances
free text keywords: *Biomedical Research Disease Eradication HIV Infections/*prevention & control Humans Public Health *Terminology as Topic *Eradication *HIV cure *Public health *Terminology, Public Health and Health Services, Public Health, Humans, HIV Infections, Biomedical Research, Terminology as Topic, Disease Eradication, Infectious Diseases, HIV/AIDS, Dental/Oral and Craniofacial Disease, Infection, HIV cure, Eradication, Terminology, Public aspects of medicine, RA1-1270, Debate, Public Health, Environmental and Occupational Health, HIV vaccine, Intensive care medicine, medicine.medical_specialty, medicine, business.industry, business, Cognitive reframing, Human immunodeficiency, Epidemiology, Population, education.field_of_study, education, Biostatistics, Environmental health
54 references, page 1 of 4

1.UNAIDS. UNAIDS Data 2017 [Internet]. 2017. Available: http://www.unaids.org/sites/default/files/media_asset/20170720_Data_book_2017_en.pdf

Marcus, JL, Chao, CR, Leyden, WA, Xu, L, Quesenberry, CP, Klein, DB. Narrowing the gap in life expectancy between HIV-infected and HIV-uninfected individuals with access to Care. JAIDS. 2016; 73: 39-46 [OpenAIRE] [PubMed]

Chun, TW, Stuyver, L, Mizell, SB, Ehler, LA, Mican, JA, Baseler, M. Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy. Proc Natl Acad Sci U S A. 1997; 94: 13193-13197 [OpenAIRE] [PubMed] [DOI]

4.TAG. Research Toward a Cure Trials [Internet]. 2017. Available: http://www.treatmentactiongroup.org/cure/trials

5.FDA. Backgrounder for FDA’s HIV Patient-Focused Drug Development and HIV Cure Research Public Meeting [Internet]. 2013. Available: http://www.fda.gov/downloads/ForIndustry/UserFees/PrescriptionDrugUserFee/UCM354549.pdf

6.Fauci A. Sustained ART-free HIV remission: opportunities and obstacles. International AIDS Society 2017. Available: http://programme.ias2017.org/Search/Search?search=Fauci

Allers, K, Hütter, G, Hofmann, J, Loddenkemper, C, Rieger, K, Thiel, E. Evidence for the cure of HIV infection by CCR5Δ32/Δ32 stem cell transplantation. Blood. 2011; 117: 2791-2799 [OpenAIRE] [PubMed] [DOI]

8.Dowdle W. Principles of Disease Elimination and Eradication. In: MMWR Morb Mortal Wkly Rep [Internet]. 1999 [cited 18 Sep 2017] pp. 23–7. Available: https://www.cdc.gov/mmwr/preview/mmwrhtml/su48a7.htm

9.CDC. Recommendations of the International Task Force for Disease Eradication. MMWR. 1993;42: 46 pages. Available: https://www.cdc.gov/mmwr/PDF/rr/rr4216.pdf

Spivak, AM, Planelles, V. HIV-1 eradication: early trials (and tribulations). Trends Mol Med Elsevier Ltd. 2016; 22: 10-27 [OpenAIRE] [DOI]

Margolis, DM. Eradication Therapies for HIV Infection: Time to Begin Again. AIDS Res Hum Retroviruses. 2011; 27 (4): 347-353 [OpenAIRE] [PubMed] [DOI]

Archin, N, Sung, J, Garrido, C, Soriano-Sarabia, N, Eradicating, MD. HIV-1 infection: seeking to clear a persistent pathogen. Nat Rev Microbiol. 2014; 12: 750-764 [OpenAIRE] [PubMed] [DOI]

Martin, AR, Siliciano, RF. Progress Toward HIV eradication: case reports, current efforts, and the challenges associated with cure. Annu Rev Med. 2016; 67: 1-14 [OpenAIRE] [PubMed] [DOI]

Zhang, J, Crumpacker, C. Eradication of HIV and cure of AIDS, now and how?. Front Immunol. 2013; 4: 337 [OpenAIRE] [PubMed] [DOI]

Tateishi, H, Monde, K, Anraku, K, Koga, R, Hayashi, Y. A Clue to Unprecedented Strategy to HIV Eradication: “Lock-in and apoptosis.” Sci Rep. Springer US. 2017; 7: 8957 [OpenAIRE]

54 references, page 1 of 4
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publication . Article . Other literature type . 2018

Use of ‘eradication’ in HIV cure-related research: a public health debate

Dubé, Karine; Luter, Stuart; Lesnar, Breanne; Newton, Luke; Galea, Jerome; Brown, Brandon; Gianella, Sara;