Tetanic stimulation leads to increased accumulation of Ca2+ calmodulin-dependent protein kinase II via dendritic protein synthesis in hippocampal neurons

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Rosenstein, Alan; Kreiman, Gabriel; Schuman, Erin M; Kennedy, Mary;
  • Publisher: Society for Neuroscience
  • Subject:
    mesheuropmc: cardiovascular system | nervous system | enzymes and coenzymes (carbohydrates) | musculoskeletal, neural, and ocular physiology | environment and public health

mRNA for the alpha-subunit of CaMKII is abundant in dendrites of neurons in the forebrain (Steward, 1997). Here we show that tetanic stimulation of the Schaffer collateral pathway causes an increase in the concentration of alpha-CaMKII in the dendrites of postsynaptic n... View more
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