publication . Doctoral thesis . 2015

The Role of CD39 in Modulating Effector Immune Responses in Inflammatory Bowel Disease

Huang, Huang;
Open Access English
  • Published: 01 Jan 2015
  • Publisher: Harvard University
  • Country: United States
Abstract
Inflammatory bowel disease is associated with excessive inflammation of the bowel and intestinal tissues in genetically susceptible individuals. IBD can manifest in two major forms, ulcerative colitis and Crohn’s disease. T helper type 17 cells (Th17) are effector lymphocytes that have been linked to intestinal inflammation in both mice and humans. Effector Th17 cells and regulatory T cells (Treg) – a subset pivotal to immune-tolerance maintenance – derive from the same CD4 progenitors. Our investigation demonstrates that Th17 cells with suppressor activity (supTh17) can be generated upon induced regulatory T cell (iTreg) exposure to Th17 polarizing conditions. ...
Subjects
Medical Subject Headings: chemical and pharmacologic phenomena
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