publication . Article . 2014

Exposition orale aux nanoparticules de dioxyde de titane (TiO2) : du franchissement de l’épithélium buccal et intestinal au devenir et aux effets dans l’organisme

Eric Houdeau; Sarah Bettini;
Open Access French
  • Published: 01 Jan 2014
  • Publisher: HAL CCSD
  • Country: France
As we are faced with the exponential use of nanomaterials in consumer products, including food, the consequences of daily exposure to nanoparticles at low doses set public health issues for humans. Among the different routes of exposure, the oral route remains the less documented, although nanomaterials are commonly used as food additives, or incorporated into packaging in contact with food or water, to provide their texturing and anti-microbial properties, or as simple colorant agents. The oral and gastrointestinal mucosa are the first regions in contact with the ingested nanoparticles. The latter cross these biological barriers, and distribute to the systemic ...
free text keywords: nanoparticules, additif alimentaire E171, muqueuses buccales, barrière intestinale, système immunitaire, nanoparticles, white food pigment E171, buccal mucosa, intestinal barrier, immune system, [SDV]Life Sciences [q-bio], General Biochemistry, Genetics and Molecular Biology, nanoparticules;additif alimentaire E171;muqueuses buccales;barrière intestinale;système immunitaire;nanoparticles;white food pigment E171;buccal mucosa;intestinal barrier;immune system, Molecular biology, Chemistry
43 references, page 1 of 3

Afssa mars 2009.

Ahlinder L., Ekstrand-Hammarstr¨om B., Geladi P., Osterlund L., Large uptake of titania and iron. Oxide nanoparticules in the nucleus of lung epithelial cells as measured by Raman Imaging and multivariate classification. Biophys J, 2013, 105, 310-319.

Becker H.M., Bertschinger M.M., Rogler G., Microparticles and their impact on intestinal immunity. Dig Dis, 2012, 30, 47-54.

Brun E., Carri`ere M., Mabondzo A., In vitro evidence of dysregulation of blood-brain barrier function after acute and repeated/long-term exposure to TiO(2) nanoparticles. Biomaterials, 2012, 333, 886-896. [OpenAIRE]

Brun E., Barreau F., Veronesi G., Fayard B., Sorieul S., Chan´eac C., Carapito C., Rabilloud T., Mabondzo A., Herlin-Boime N., Carri`ere M., Titanium dioxide nanoparticle impact and translocation through ex vivo, in vivo and in vitro gut epithelia. Part Fibre Toxicol, 2014, 11, 13.

Chen X.X., Cheng B., Yang Y.X., Cao A., Liu J.H., Du L.J., Liu Y., Zhao Y., Wang H.,Characterization and preliminary toxicity assay of nano-titanium dioxide additive in sugar-coated chewing gum. Small, 2013, 9, 1765-1774.

Cho W.S., Kang B.C., Lee J.K., Jeong J., Che J.H., Seok S.H., Comparative absorption, distribution, and excretion of titanium dioxide and zinc oxide nanoparticles after repeated oral administration. Part Fibre Toxicol, 2013, 10, 9. [OpenAIRE]

Duan Y., Liu J., Ma L., Li N., Liu H., Wang J., Zheng L., Liu C., Wang X., Zhao X., Yan J., Wang S., Wang H., Zhang X., Hong F., Toxicological characteristics of nanoparticulate anatase titanium dioxide in mice. Biomaterials, 2010, 31, 894-899.

Geraets L., Oomen A.G., Krystek P., Jacobsen N.R., Wallin H., Laurentie M., Verharen H.W., Brandon E.F., de Jong W.H., Tissue distribution and elimination after oral and intravenous administration of different titanium dioxide nanoparticles in rats. Part Fibre Toxicol, 2014, 11, 30. [OpenAIRE]

Giovanni M., Tay C.Y., Setyawati M.I., Xie J., Ong C.N., Fan R., Yue J., Zhang L., Leong D.T., Toxicity profiling of water contextual zinc oxide, silver, and titanium dioxide nanoparticles in human oral and gastrointestinal cell systems. Environ Toxicol, 2014 [doi: 10.1002/tox.22015].

Gottschalk F., Sonderer T., Scholz R.W., Nowack B., Modeled environmental concentrations of engineered nanomaterials (TiO(2), ZnO, Ag, CNT, Fullerenes) for different regions. Environ Sci Technol, 2009, 43, 9216−9222.

Harris D., Robinson JR., Drug delivery via the mucous membranes of the oral cavity. J Pharm Sci, 1992, 81, 1-10.

Houdeau E., Nanoparticules et barri`ere intestinale : comprendre les m´ecanismes de franchissement. Innov Agro, 2012, 24, 105-112. [OpenAIRE]

Janer G., Mas del Molino E., Ferna´ndez-Rosas E., Ferna´ndez A., Va´zquez-Campos S., Cell uptake and oral absorption of titanium dioxide nanoparticles. Toxicol Lett, 2014, 228, 103-110.

Jin C., Tang Y., Fan X.Y., Ye X.T., Li X.L., Tang K., Zhang Y.F., Li A.G., Yang Y.J., In vivo evaluation of the interaction between titanium dioxide nanoparticle and rat liver DNA. Toxicol Ind Health, 2013, 29, 235−244.

43 references, page 1 of 3
Any information missing or wrong?Report an Issue