publication . Conference object . 2017

Myofiber metabolic type determination by mass spectrometry imaging

Théron, Laetitia; Vénien, Annie; Pujos-Guillot, Estelle; Astruc, Thierry; Chambon, Christophe;
Open Access English
  • Published: 01 Jan 2017
Abstract
In muscle imaging, myofiber type determination is of great importance to better understand biological mechanisms related to skeletal muscle changes associated with pathologies. However, reference methods (histo-enzymology and immunohistochemistry) require serial-cross sections, and several days from the sampling to the results of image analysis. In this work, a strategy based on MALDI-Mass Spectrometry Imaging was developed as an alternative to the classical methods for myofiber metabolic type determination. The spectra were acquired on an Autoflex Speed MALDI-TOF/TOF mass spectrometer with a Smartbeam laser (Bruker Daltonics) in positive linear mode at a mass r...
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Subjects
free text keywords: Alimentation et Nutrition, Food and Nutrition, Bio-informatique, Bioinformatics, Chimie analytique, Analytical chemistry, imagerie;modèle prédictif;muscle, muscle squelettique, myofibre, MALDI, mécanisme biologique
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Conference object . 2017
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