publication . Article . 2010

Selective bromination of 4-chloro-1-indanone and synthesis of (4-chloro-2, 3-dihydro-1H-indene-2-yl)methanamine

Jasouri, S.; Khalafy, J.; Badali, M.; Piltan, M.;
Open Access English
  • Published: 01 Jan 2010
  • Publisher: The South African Chemical Institute
Abstract
The synthesis of 4-chloro-1-indanone in four steps from 2-chlorobenzaldehyde was investigated. Bromination of this compound under various conditions occurred in the cyclopentanone ring, producing mono- and dibromo derivatives. Cyanation of 2-bromo-4-chloro-1-indanone followed by reduction gave (4-chloro-2, 3-dihydro-1H-indene-2-yl)methanamine in quantitative yield.
Subjects
free text keywords: Indanone, bromination, cyanation, reduction, GABA B receptors
Related Organizations
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