publication . Article . 2014

Photoactive assemblies of organic compounds and biomolecules: drug–protein supramolecular systems

Vayá Pérez, Ignacio; Lhiaubet-Vallet, Virginie Lyria; Jiménez Molero, María Consuelo; Miranda Alonso, Miguel Ángel;
Open Access
  • Published: 17 Jul 2014 Journal: Chem. Soc. Rev., volume 43, pages 4,102-4,122 (issn: 0306-0012, eissn: 1460-4744, Copyright policy)
  • Publisher: Royal Society of Chemistry (RSC)
  • Country: Spain
Abstract
[EN] The properties of singlet and triplet excited states are strongly medium-dependent. Hence, these species constitute valuable tools as reporters to probe compartmentalised microenvironments, including drug@protein supramolecular systems. In the present review, the attention is focused on the photophysical properties of the probe drugs (rather than those of the protein chromophores) using transport proteins (serum albumins and 1-acid glycoproteins) as hosts. Specifically, fluorescence measurements allow investigating the structural and dynamic properties of biomolecules or their complexes. Thus, the emission quantum yields and the decay kinetics of the drug ...
Subjects
free text keywords: Acid glycoproteins, Fluorescence, Laser flash photolysis, Serum albumins, Photoreactivity, Protein binding, QUIMICA ORGANICA, QUIMICA ANALITICA, General Chemistry, Biomolecule, chemistry.chemical_classification, chemistry, Chromophore, Supramolecular chemistry, Binding constant, Photochemistry, Organic chemistry, Plasma protein binding, Flash photolysis, Singlet state, Förster resonance energy transfer, Nanotechnology, Drug, media_common.quotation_subject, media_common
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