publication . Article . 2016

The (6-4) Dimeric Lesion as a DNA Photosensitizer.

Vendrell Criado, Victoria; Rodríguez Muñiz, Gemma María; Lhiaubet ., Virginie Lyria; Cuquerella Alabort, Maria Consuelo; Miranda Alonso, Miguel Ángel;
Open Access
  • Published: 31 Mar 2016 Journal: ChemPhysChem, volume 17, pages 1,979-1,982 (issn: 1439-4235, Copyright policy)
  • Publisher: Wiley
  • Country: Spain
Abstract
[EN] Based on our previous investigations into the photophysical properties of the 5-methyl-2-pyrimidone (Pyo) chromophore, we now extend our studies to the photobehavior of the dimeric (6-4) thymine photoproducts (6-4 PP) to evaluate their capability to act as instrinsic DNA photosensitizers. The lesion presents significant absorption in the UVB/UVA region, weak fluorescence emission, a singlet-excited-state energy of approximately 351 kJ mol(-1), and a triplet-excited-state energy of 297 kJ mol(-1). Its triplet transient absorption has a maximum at 420-440 nm, a lifetime of around 7 mu s, and a high formation quantum yield, Phi(ISC) = 0.86. This species is eff...
Subjects
free text keywords: Cyclobutane pyrimidine dimers, DNA damage, Triplet excited states, QUIMICA ORGANICA, QUIMICA ANALITICA, Photochemistry, Cyclobutane, chemistry.chemical_compound, chemistry, Chromophore, Fluorescence, Pyrimidine dimer, Pyrimidone, Quantum yield, Photosensitizer, Thymine
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publication . Article . 2016

The (6-4) Dimeric Lesion as a DNA Photosensitizer.

Vendrell Criado, Victoria; Rodríguez Muñiz, Gemma María; Lhiaubet ., Virginie Lyria; Cuquerella Alabort, Maria Consuelo; Miranda Alonso, Miguel Ángel;