publication . Doctoral thesis . 2015

Genomic diversity of Lactobacillus salivarius

Raftis, Emma J.;
Open Access English
  • Published: 01 Jan 2015
  • Publisher: University College Cork
  • Country: Ireland
Abstract
Lactobacillus salivarius is unusual among the lactobacilli due to its multireplicon genome architecture. The circular megaplasmids harboured by L. salivarius strains encode strain-specific traits for intestinal survival and probiotic activity. L. salivarius strains are increasingly being exploited for their probiotic properties in humans and animals. In terms of probiotic strain selection, it is important to have an understanding of the level of genomic diversity present in this species. Comparative genomic hybridization (CGH) and multilocus sequence typing (MLST) were employed to assess the level of genomic diversity in L. salivarius. The wellcharacterised prob...
Subjects
free text keywords: Comparative genomics, Lactobacillus salivarius, Megaplasmid
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