publication . Article . 2007

A PTH/PTHrP receptor antagonist blocks the hypercalcemic response to estradiol-17b

Fuentes, J.; Guerreiro, P. M.; Modesto, Teresa; Rotllant, J.; Canario, Adelino V. M.; Power, Deborah;
Open Access English
  • Published: 30 May 2007
  • Publisher: American Physiological Society
  • Country: Portugal
Abstract
Estradiol (E2) increases circulating calcium and phosphate levels in fish, thus acting as a hypercalcemic and hyperphosphatemic factor during periods of high calcium requirements, such as during vitellogenesis. Since parathyroid hormone (PTH)-related protein (PTHrP) has been shown to be calciotropic in fish, we hypothesized that the two hormones could be mediating the same process. Sea bream (Sparus auratus) juveniles receiving a single intraperitoneal injection of piscine PTHrP(1-34) showed an elevation in calcium plasma levels within 24 h. In contrast, injections of the PTH/PTHrP receptor antagonist PTHrP(7-34) decreased circulating levels of calcium in the sa...
Subjects
Medical Subject Headings: hormones, hormone substitutes, and hormone antagonists
free text keywords: Fish, Calcium, Phosphate
Related Organizations
Funded by
FCT| POCTI/CVT/48946/2002
Project
POCTI/CVT/48946/2002
Physiology of PTHrP in fish, relevance to calcium balance of an unique hypercalcemic factor
  • Funder: Fundação para a Ciência e a Tecnologia, I.P. (FCT)
  • Project Code: 48946
  • Funding stream: POCI
Communities
European Marine Science
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Article . 2007
Provider: Sapientia
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