publication . Master thesis . 2014

Structural characterization and comparative analysis of human and piscine cartilage acidic protein (CRTAC1/CRTAC2)

Guerreiro, Marta Lúcia Amaro;
Open Access English
  • Published: 01 Jan 2014
  • Country: Portugal
Abstract
Dissertação de mestrado, Biotecnologia, Faculdade de Ciências e Tecnologia, Universidade do Algarve, 2014 CRTAC (Cartilage Acidic Protein) firstly identified as a chondrocyte marker in humans and implicated in a number of diseases. This ancient protein is present from prokaryotes to vertebrates and the teleost are the only group that contain duplicates (CRTAC1/CRTAC2). The structure of CRTACs is poorly characterized and was the starting point of the present study. To establish the molecular and structural characterization of CRTAC, three recombinant proteins [human (h) CRTAC1 and sea bass (Dicentrarchus labrax, dl) CRTAC1 and CRTAC2] were over-expressed in E.col...
Subjects
free text keywords: CRTAC, β-sheet, Thermostability, Diseases, Amyloid, Structure, :Engenharia e Tecnologia::Outras Engenharias e Tecnologias [Domínio/Área Científica]
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