publication . Article . Other literature type . 2014

Correlation of Helicobacter pylori genotypes with gastric histopathology in the central region of a South-European country

Nuno Almeida; Maria Manuel Donato; José Manuel Romãozinho; Cristina Luxo; Olga Cardoso; Maria Augusta Cipriano; Carol Marinho; Alexandra Fernandes; Carlos Sofia;
Open Access English
  • Published: 21 Aug 2014
  • Country: Portugal
Abstract
BACKGROUND: Outcome of Helicobacter pylori (H. pylori) infection results from interaction of multiple variables including host, environmental and bacterial-associated virulence factors. AIM: This study aimed to investigate the correlation of cagA, cagE, vacA, iceA and babA2 genotypes with gastric histopathology and disease phenotype in the central region of a South-European country. METHODS: This prospective study involved 148 infected patients (110 female; mean age 43.5 ± 13.4 years) submitted to endoscopy with corpus and antrum biopsies. H. pylori was cultured and DNA extracted from the isolates. Genotypes were determined by PCR. Histopathological features wer...
Subjects
Medical Subject Headings: digestive system diseasesbacterial infections and mycosesbacteria
free text keywords: Helicobacter pylori, Infecções por Helicobacter, Gastrite, Virulence, Gastroenterology, Physiology, Diabetes mellitus, medicine.disease, medicine, Endocrinology, medicine.medical_specialty, business.industry, business, CagA, biology.organism_classification, biology, Genotype, Gastritis, medicine.symptom, Internal medicine, Histopathology
Funded by
FCT| PIC/IC/83122/2007
Project
PIC/IC/83122/2007
Study of Helicobacter pylori primary and secondary resistance to antimicrobial agents
  • Funder: Fundação para a Ciência e a Tecnologia, I.P. (FCT)
  • Project Code: 83122
  • Funding stream: 5876-PPCDTI
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publication . Article . Other literature type . 2014

Correlation of Helicobacter pylori genotypes with gastric histopathology in the central region of a South-European country

Nuno Almeida; Maria Manuel Donato; José Manuel Romãozinho; Cristina Luxo; Olga Cardoso; Maria Augusta Cipriano; Carol Marinho; Alexandra Fernandes; Carlos Sofia;