publication . Article . 2013

Birth, death and horizontal transfer of a gene cluster

Robert H. Proctor; François Van Hove; Antonia Susca; Gaetano Stea; Mark Busman; Theo van der Lee; Cees Waalwijk; Antonio Moretti; Todd J. Ward;
Open Access English
  • Published: 28 Aug 2013
  • Country: Belgium
Abstract
Summary: Fumonisins are a family of carcinogenic secondary metabolites produced by members of the Fusarium fujikuroi species complex (FFSC) and rare strains of Fusarium oxysporum. In Fusarium, fumonisin biosynthetic genes (FUM) are clustered, and the cluster is uniform in gene organization. Here, sequence analyses indicated that the cluster exists in five different genomic contexts, defining five cluster types. In FUM gene genealogies, evolutionary relationships between fusaria with different cluster types were largely incongruent with species relationships inferred from primary-metabolism (PM) gene genealogies, and FUM cluster types are not trans-specific. In a...
Subjects
Medical Subject Headings: food and beverages
free text keywords: Molecular Biology, Microbiology, Phylogenetics, Gene cluster, Genetics, Biology, Gene duplication, Comparative genomics, Gene, Balancing selection, Horizontal gene transfer, Fusarium, biology.organism_classification
Abstract
Summary: Fumonisins are a family of carcinogenic secondary metabolites produced by members of the Fusarium fujikuroi species complex (FFSC) and rare strains of Fusarium oxysporum. In Fusarium, fumonisin biosynthetic genes (FUM) are clustered, and the cluster is uniform in gene organization. Here, sequence analyses indicated that the cluster exists in five different genomic contexts, defining five cluster types. In FUM gene genealogies, evolutionary relationships between fusaria with different cluster types were largely incongruent with species relationships inferred from primary-metabolism (PM) gene genealogies, and FUM cluster types are not trans-specific. In a...
Subjects
Medical Subject Headings: food and beverages
free text keywords: Molecular Biology, Microbiology, Phylogenetics, Gene cluster, Genetics, Biology, Gene duplication, Comparative genomics, Gene, Balancing selection, Horizontal gene transfer, Fusarium, biology.organism_classification
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publication . Article . 2013

Birth, death and horizontal transfer of a gene cluster

Robert H. Proctor; François Van Hove; Antonia Susca; Gaetano Stea; Mark Busman; Theo van der Lee; Cees Waalwijk; Antonio Moretti; Todd J. Ward;