The Effects of Dietary Calcium and/or Iron Deficiency upon Murine Intestinal Calcium Binding Protein Activity and Calcium Absorption
Other literature type
McDonald, Catherine M.
- Publisher: DigitalCommons@USU
Iron deficiency has been shown to impair calcium absorption, leading to decreased bone mass. Vitamin D3-dependent calcium binding protein (CaBP) has been demonstrated to be necessary for the active transport of calcium in the intestine of numerous species. Iron deficiency might affect the activity of the calcium binding protein.
Four experimental diets were formulated as follows: Diet 1, iron adequate, calcium adequate; Diet 2, iron deficient, calcium adequate; Diet 3, iron adequate, calcium deficient; Diet 4, iron deficient, calcium deficient. Weanling, female rats were separated into 4 groups of 48 animals each and fed the respective diet for a period of 66 or 67 days.
Results of a 10-day metabolic study indicate that animals fed either the iron adequate, calcium deficient or iron deficient, calcium deficient diets adapted to the calcium deficiency in a comparable manner. The percent apparent calcium absorption in the animals fed the iron adequate, calcium deficient or iron deficient, calcium deficient diets was more than double (p < 0.01) the percent apparent calcium absorption of the animals fed the iron adequate, calcium adequate or iron deficient, calcium adequate diets.