publication . Doctoral thesis . 2017

Unveil the complexity of the molecular machinery involved in erythrophagocytosis by macrophages

Santarino, Inês Barreira;
Open Access English
  • Published: 18 Jul 2017
  • Country: Portugal
Abstract
ABSTRACT: Erythrophagocytosis is a highly regulated process where sequential events ensure the proper internalization and clearance of red blood cells. However, details on these processes are scarce and not fully understood, making it difficult to modulate and possibly treat associated diseases, such as malaria and sickle-cell disease. After their development in the bone marrow, red blood cells have a life span of approximately 120 days. With time, the plasma membrane of red blood cells undergoes deleterious changes that make the cell susceptible to clearance by macrophages – a process known as senescence. Before this process, erythrocytes may undergo cell death...
Subjects
free text keywords: Molecular and Cellular Biology, Erythrophagocytosis, Red Blood Cells, Biologia Molecular e Celular, Glóbulos Vermelhos, Eritrofagocitose, Ciências Médicas
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