BDNF gene delivery mediated by neuron-targeted nanoparticles is neuroprotective in peripheral nerve injury.

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Lopes, C; Gonçalves, N; Gomes, C; Saraiva, M; Pêgo, AP;
(2017)
  • Publisher: Elsevier
  • Journal: Lopes , C D , Goncalves , N P , Gomes , CP , Saraiva , M J & Pego , A P 2017 , ' BDNF gene delivery mediated by neuron-targeted nanoparticles is neuroprotective in peripheral nerve injury. ' , Biomaterials , pp. 83 .-Lopes , C D , Goncalves , N P , Gomes , CP , Saraiva , M J & Pego , A P 2017 , ' BDNF gene delivery mediated by neuron-targeted nanoparticles is neuroprotective in peripheral nerve injury. ' , Biomaterials , pp. 83 .issn: 0142-9612
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1016/j.biomaterials.2016.12.025
  • Subject: Peripheral Nerve Injuries/pathology | Neurons/chemistry | Plasmids/genetics | Genetic Therapy/methods | Gene therapy | Brain-Derived Neurotrophic Factor/genetics | Mice | Treatment Outcome | Neuron-targeted nanoparticles | Peripheral Nerve Injuries/genetics | Mice Inbred BALB C | Plasmids/administration & dosage | Neuroprotection | Peripheral Nerve Injuries/therapy | Neuropathies | Nanocapsules/chemistry | Brain-derived neurotrophic factor | Trimethyl chitosan | Animals | Female | Nanocapsules/administration & dosage

Neuron-targeted gene delivery is a promising strategy to treat peripheral neuropathies. Here we propose the use of polymeric nanoparticles based on thiolated trimethyl chitosan (TMCSH) to mediate targeted gene delivery to peripheral neurons upon a peripheral and minimal... View more
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