BDNF gene delivery mediated by neuron-targeted nanoparticles is neuroprotective in peripheral nerve injury.

Article English EMBARGO
Lopes, Catia D ; Goncalves, Nádia Pereira ; Gomes, CP ; Saraiva, Maria J ; Pego, Ana P (2017)
  • Publisher: Elsevier
  • Journal: Lopes , C D , Goncalves , N P , Gomes , CP , Saraiva , M J & Pego , A P 2017 , ' BDNF gene delivery mediated by neuron-targeted nanoparticles is neuroprotective in peripheral nerve injury. ' Biomaterials , pp. 83 .-Lopes , C D , Goncalves , N P , Gomes , CP , Saraiva , M J & Pego , A P 2017 , ' BDNF gene delivery mediated by neuron-targeted nanoparticles is neuroprotective in peripheral nerve injury. ' Biomaterials , pp. 83 . (issn: 0142-9612)
  • Related identifiers: doi: 10.1016/j.biomaterials.2016.12.025
  • Subject: Peripheral Nerve Injuries/pathology | Neurons/chemistry | Plasmids/genetics | Genetic Therapy/methods | Brain-Derived Neurotrophic Factor/genetics | Mice | Treatment Outcome | Peripheral Nerve Injuries/genetics | Mice Inbred BALB C | Plasmids/administration & dosage | Peripheral Nerve Injuries/therapy | Nanocapsules/chemistry | Animals | Female | Nanocapsules/administration & dosage
    mesheuropmc: nervous system

Neuron-targeted gene delivery is a promising strategy to treat peripheral neuropathies. Here we propose the use of polymeric nanoparticles based on thiolated trimethyl chitosan (TMCSH) to mediate targeted gene delivery to peripheral neurons upon a peripheral and minimal... View more
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