publication . Article . 2014

Development and Validation of a Fast Procedure to Analyze Amoxicillin in River Waters by Direct-Injection LC-MS/MS.

Alves, Arminda; Lúcia Santos; V. Homem;
Open Access
  • Published: 07 Oct 2014 Journal: Journal of Chemical Education, volume 91, pages 1,961-1,965 (issn: 0021-9584, eissn: 1938-1328, Copyright policy)
  • Publisher: American Chemical Society (ACS)
  • Country: Portugal
A laboratory application with a strong component in analytical chemistry was designed for undergraduate students, in order to introduce a current problem in the environmental science field, the water contamination by antibiotics. Therefore, a simple and rapid method based on direct injection and high performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed and optimized for the determination of amoxicillin in river water. Students learned the main optimization steps for the improvement of the LC-MS/MS methodology and the correct procedure to validate an analytical method (draw a calibration curve, determine detection and quantification...
free text keywords: Engenharia do ambiente, Environmental engineering, :Engenharia do ambiente [Ciências da engenharia e tecnologias], :Environmental engineering [Engineering and technology], General Chemistry, Education
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