Recycling antimalarial leads for cancer: Antiproliferative properties of N-cinnamoyl chloroquine analogues

Article English OPEN
Bianca C Perez; Iva Fernandes; Nuno Mateus; Catia Teixeira; Paula Gomes;
(2013)
  • Publisher: PERGAMON-ELSEVIER SCIENCE LTD
  • Related identifiers: doi: 10.1016/j.bmcl.2013.10.025
  • Subject: INHIBITORS | EXPRESSION | :Health sciences [Medical and Health sciences] | Ciências da saúde | :Ciências da saúde [Ciências médicas e da saúde] | Health sciences | AGENTS | DRUG | ACID | CELLS | PHENYL NITROGEN-MUSTARD | GROWTH | DISTAMYCIN | HALF-MUSTARD DERIVATIVES

Cinnamic acids and quinolines are known as useful scaffolds in the discovery of antitumor agents. Therefore, N-cinnamoylated analogues of chloroquine, recently reported as potent dual-action antimalarials, were evaluated against three different cancer cell lines: MKN-28... View more