publication . Doctoral thesis . 2012

Regulation of neuroinflammation by cGMP-mediated pathways

Prado Sánchez, Judith; Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular;
Open Access English
  • Published: 02 Jul 2012
  • Publisher: [Barcelona] : Universitat Autònoma de Barcelona,
  • Country: Spain
Abstract
In the present work we investigated the involvement of intracellular cGMP levels in regulating different aspects of neuroinflammation. In the first chapter we observed that cultured rat astrocytes and microglial cells express the necessary machinery to synthesize cGMP in response NPs and to degrade the nucleotide. We also investigated the effects of NP stimulation in the expression of the pro-inflammatory protein iNOS. We observed that pretreatment with ANP down-regulates iNOS protein levels induced by the pro-inflammatory agent LPS by an NPR-A-PKG dependent mechanism in rat cultured microglial cells. In addition we found that this down-regulation seems to be do...
Subjects
free text keywords: Àcid guanílic cíclic, Sistema nerviós Malalties, Inflamació, CGMP, Neuroinflammation, Neuroprotection, Ciències de la Salut, 577
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publication . Doctoral thesis . 2012

Regulation of neuroinflammation by cGMP-mediated pathways

Prado Sánchez, Judith; Universitat Autònoma de Barcelona. Departament de Bioquímica i Biologia Molecular;