publication . Article . Other literature type . 2017

VGKC and GAD antibodies in psychosis

Grain, Rosemary; Lally, John; Stubbs, Brendon; Malik, Steffi; LeMince, Anne; Nicholson, Timothy R.; Murray, Robin M.; Gaughran, Fiona;
Open Access
  • Published: 01 Oct 2017 Journal: Psychiatry and Clinical Neurosciences, volume 71, pages 678-689 (issn: 1323-1316, Copyright policy)
  • Publisher: Wiley
Antibodies to the voltage-gated potassium channel (VGKC) complex and glutamic acid decarboxylase (GAD) have been reported in some cases of psychosis. We conducted the first systematic review and meta-analysis to investigate their prevalence in people with psychosis and report a case series of VGKC-complex antibodies in refractory psychosis. Only five studies presenting prevalence rates of VGKC seropositivity in psychosis were identified, in addition to our case series, with an overall prevalence of 1.5% (25/1720) compared to 0.7% in healthy controls (12/1753). Meta-analysis established that the pooled prevalence of GAD65 autoantibodies was 5.8% (95% confidence i...
free text keywords: Antibodies, encephalitis, glutamic acid decarboxylase, voltage-gated potassium channel complex., Medicine and Health Sciences, Psychiatry and Psychology, Antibodies; Encephalitis; Glutamic acid decarboxylase; Schizophrenia; Voltage-gated potassium channel complex, Prevalence, Psychology, Schizophrenia, medicine.disease, medicine, Type 1 diabetes, Odds ratio, Psychiatry, medicine.medical_specialty, Psychosis, Meta-analysis, Glutamate decarboxylase, Bipolar disorder
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