Estrogen inhibits chloride secretion caused by cholera and Escherichia coli enterotoxins in female rat distal colon.
Other literature type
Harvey, Brian J
- Publisher: e-publications@RCSI
8-Bromo Cyclic Adenosine Monophosphate | Androgens | Animals | Bacterial Toxins | Chloride Channels | Chlorides | Cholera Toxin | Colon | Cyclic GMP | Enterotoxins | Enzyme Activation | Epithelium | Escherichia coli | Estradiol | Estrogens | Female | KCNQ1 Potassium Channel | Male | Membrane Potentials | Progesterone | Progestins | Protein Kinase C-delta | Rats | Sprague-Dawley | Testosterone | Rats, Sprague-Dawley | Medical Molecular Biology | Medical Sciences
Excessive Cl(-) secretion is the driving force for secretory diarrhea. 17β-Estradiol has been shown to inhibit Cl(-) secretion in rat distal colon through a nongenomic pathway. We examined whether 17β-estradiol inhibits Cl(-) secretion in an animal model of secretory di...