publication . Article . Other literature type . 2011

Estrogen inhibits chloride secretion caused by cholera and Escherichia coli enterotoxins in female rat distal colon.

Alzamora, Rodrigo; O'Mahony, Fiona; Harvey, Brian J;
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  • Published: 01 Aug 2011 Journal: Steroids (issn: 0039-128X, Copyright policy)
  • Publisher: Elsevier BV
  • Country: Bahrain
Abstract
Abstract Excessive Cl − secretion is the driving force for secretory diarrhea. 17β-Estradiol has been shown to inhibit Cl − secretion in rat distal colon through a nongenomic pathway. We examined whether 17β-estradiol inhibits Cl − secretion in an animal model of secretory diarrhea and the downstream effectors involved. The effect of 17β-estradiol on cholera toxin and heat-stable enterotoxin induced Cl − secretion in rat colonic mucosal sheets was studied by current–voltage clamping. Selective permeabilization of apical or basolateral membranes with amphotericin B or nystatin was used to isolate basolateral K + channel and apical Cl − channel activity, respectiv...
Subjects
free text keywords: 8-Bromo Cyclic Adenosine Monophosphate, Androgens, Animals, Bacterial Toxins, Chloride Channels, Chlorides, Colon, Cyclic GMP, Enterotoxins, Enzyme Activation, Escherichia coli, Estradiol, Estrogens, Female, KCNQ1 Potassium Channel, Male, Membrane Potentials, Progesterone, Progestins, Protein Kinase C-delta, Rats, Sprague-Dawley, Testosterone, Rats, Sprague-Dawley, Medical Molecular Biology, Medical Sciences, Organic Chemistry, Clinical Biochemistry, Biochemistry, Molecular Biology, Pharmacology, Endocrinology, Enzyme activator, Epithelium, medicine.anatomical_structure, medicine, Chemistry, Chloride channel, Cholera toxin, medicine.disease_cause, medicine.medical_specialty, Internal medicine, Membrane potential, Secretion, Enterotoxin, Second messenger system
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publication . Article . Other literature type . 2011

Estrogen inhibits chloride secretion caused by cholera and Escherichia coli enterotoxins in female rat distal colon.

Alzamora, Rodrigo; O'Mahony, Fiona; Harvey, Brian J;