Estrogen inhibits chloride secretion caused by cholera and Escherichia coli enterotoxins in female rat distal colon.

Other literature type OPEN
Alzamora, Rodrigo ; O'Mahony, Fiona ; Harvey, Brian J (2011)
  • Publisher: e-publications@RCSI
  • Subject: 8-Bromo Cyclic Adenosine Monophosphate | Androgens | Animals | Bacterial Toxins | Chloride Channels | Chlorides | Cholera Toxin | Colon | Cyclic GMP | Enterotoxins | Enzyme Activation | Epithelium | Escherichia coli | Estradiol | Estrogens | Female | KCNQ1 Potassium Channel | Male | Membrane Potentials | Progesterone | Progestins | Protein Kinase C-delta | Rats | Sprague-Dawley | Testosterone | Rats, Sprague-Dawley | Medical Molecular Biology | Medical Sciences

Excessive Cl(-) secretion is the driving force for secretory diarrhea. 17β-Estradiol has been shown to inhibit Cl(-) secretion in rat distal colon through a nongenomic pathway. We examined whether 17β-estradiol inhibits Cl(-) secretion in an animal model of secretory di... View more
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