Novel micellar systems for the formulation of poorly water soluble drugs : biocompatibility aspects and pharmaceutical applications
Dumontet Mondon, Karine
- Publisher: Université de Genève
Antifungal | Biocompatibility | CAM | Cyclosporin A | Drug delivery | Econazole nitrate | Hexyl substituted polylactides | Hypericin | Micelles | Toxicity | Ovarian cancer | HexPLA | Photodiagnosis | Polymeric micelles | Skin deposition | TEM | Topical application
Amongst the large number of novel drugs, 95% are lipophilic and poorly water soluble. Particularly, this renders their aqueous formulation very difficult. In this regard this thesis focused on polymeric micelles based on novel MPEG-hexPLA copolymers forming a hydrophili...