Characterization of pancreatic transcription factor Pdx-1 binding sites using promoter microarray and serial analysis of chromatin occupancy

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Keller, David M; McWeeney, Shannon; Arsenlis, Athanasios; Drouin, Jacques; Wright, Christopher V E; Wang, Haiyan; Wollheim, Claes; White, Peter; Kaestner, Klaus H; Goodman, Richard H;
(2007)
  • Journal: issn: 0021-9258
  • Publisher copyright policies & self-archiving
  • Related identifiers: doi: 10.1074/jbc.M700899200
  • Subject: Binding Sites | Cell Differentiation | Homeodomain Proteins/metabolism | Insulin | Basic Helix-Loop-Helix Transcription Factors/metabolism | Mice | Trans-Activators/metabolism | Chromatin Immunoprecipitation | Mice, Inbred C57BL | Insulin-Secreting Cells/cytology/metabolism | Promoter Regions, Genetic | Oligonucleotide Array Sequence Analysis | Chromatin/metabolism | Animals | MicroRNAs/metabolism | Transcription, Genetic | Polymerase Chain Reaction
    • ddc: ddc:612
    mesheuropmc: endocrine system | hormones, hormone substitutes, and hormone antagonists

The homeobox transcription factor Pdx-1 is necessary for pancreas organogenesis and beta cell function, however, most Pdx-1-regulated genes are unknown. To further the understanding of Pdx-1 in beta cell biology, we have characterized its genomic targets in NIT-1 cells,... View more
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