Syntheses of sulfanylphthalimide and xanthine analogues and their evaluation as inhibitors of monoamine oxidase and as antagonists of adenosine receptors / Mietha Magdalena van der Walt
Van der Walt, Mietha Magdalena
- Publisher: North-West University
Parkinson’s disease | Monoamine oxidase | Phthalimide | Phthalonitrile | Benzonitrile | Inhibition | Adenosine A2A receptors | Antagonist | Xanthine
Currently L-DOPA is the drug most commonly used for the treatment of Parkinson’s disease
(PD). However, the long-term use of L-DOPA is associated with the development of motor
fluctuations and dyskinesias. Treatment mainly addresses the dopaminergic features of th...