Syntheses of sulfanylphthalimide and xanthine analogues and their evaluation as inhibitors of monoamine oxidase and as antagonists of adenosine receptors / Mietha Magdalena van der Walt

Doctoral thesis English OPEN
Van der Walt, Mietha Magdalena;
  • Publisher: North-West University
  • Subject: Parkinson’s disease | Monoamine oxidase | Phthalimide | Phthalonitrile | Benzonitrile | Inhibition | Adenosine A2A receptors | Antagonist | Xanthine

Currently L-DOPA is the drug most commonly used for the treatment of Parkinson’s disease (PD). However, the long-term use of L-DOPA is associated with the development of motor fluctuations and dyskinesias. Treatment mainly addresses the dopaminergic features of th... View more
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