publication . Thesis . 2011

An investigation into the role of noradrenergic receptors in conditioned fear : relevance for posttraumatic stress disorder / Erasmus M.M.

Erasmus, Madeleine Monique;
Open Access
  • Published: 01 Jan 2011
  • Publisher: North-West University
  • Country: South Africa
Abstract
Posttraumatic stress disorder is a debilitating anxiety disorder that can develop in the aftermath of a traumatic or life–threatening event involving extreme horror, intense fear or bodily harm. The disorder is typified by a symptom triad consisting of re–experiencing, hyperarousal and avoidance symptoms. Approximately 15–25% of trauma–exposed individuals go on to develop PTSD, depending on the nature and severity of the trauma. Although dysfunctional adaptive responses exist in multiple neurobiological pathways in the disorder, e.g. glutamate, GABA, glucocortocoids and serotonin, the noradrenergic system is particularly prominent and represents an important pha...
Subjects
free text keywords: PTSD, Contextual fear conditioning, Passive avoidance, Memory consolidation, Learned fear, Propranolol, Nadolol, Betaxolol, ICI 118551, Prazosin, Yohimbine, Guanfacine, Kontekstuele vreeskondisionering, Passiewe vermyding, Konsolidasie van geheue, Aangeleerde vrees, Betaksolol, Prasosien, Johimbien, Guanfasien
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