publication . Other literature type . Article . 2012

Metabotropic and ionotropic glutamate receptors as neurobiological targets in anxiety and stress-related disorders: focus on pharmacology and preclinical translational models.

Harvey, Brian H.; Shahid, Mohammed;
  • Published: 01 Feb 2012
  • Publisher: Elsevier BV
  • Country: Bangladesh
Abstract
Anxiety disorders are amongst the most common and disabling of psychiatric illnesses and have severe health and socio-economic implications. Despite the availability of a number of treatment options there is still a strong medical need for novel and improved pharmacological approaches in treating these disorders. New developments at the forefront of preclinical research have begun to identify the therapeutic potential of molecular entities integral to the biological response to adversity, particularly molecules and processes that may pre-determine vulnerability or resilience, and those that may act to switch off or “unlearn” a response to an aversive event. The ...
Subjects
free text keywords: Animal model, Anxiety disorder, Anxiolytic, Posttraumatic stress disorder, Obsessive-compulsive disorder, GABA, Glutamate, Nitric oxide, Ionotropic, Metabotropic, Translational, Drug target, Toxicology, Clinical Biochemistry, Biochemistry, Biological Psychiatry, Behavioral Neuroscience, Pharmacology, Anxiety, medicine.symptom, medicine, medicine.disease, Ionotropic effect, medicine.drug_class, Metabotropic receptor, Neuroscience, Stress-related disorders, Medical research, Psychology, Glutamate receptor
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publication . Other literature type . Article . 2012

Metabotropic and ionotropic glutamate receptors as neurobiological targets in anxiety and stress-related disorders: focus on pharmacology and preclinical translational models.

Harvey, Brian H.; Shahid, Mohammed;