publication . Thesis . 2014

Development and evaluation of a solid oral dosage form for an artesunate and mefloquine drug combination / Abel Hermanus van der Watt

Van der Watt, Abel Hermanus;
Open Access English
  • Published: 01 Jan 2014
  • Country: Paraguay
Abstract
Malaria affects about forty percent of the world’s population. Annually more than 1.5 million fatalities due to malaria occur and parasite resistance to existing antimalarial drugs such as mefloquine has already reached disturbingly high levels in South-East Asia and on the African continent. Consequently, there is a dire need for new drugs or formulations in the prophylaxis and treatment of malaria. Artesunate, an artemisinin derivative, represents a new category of antimalarials that is effective against drug-resistant Plasmodium falciparum strains and is of significance in the current antimalarial campaign. As formulating an ACT double fixed-dose combination ...
Subjects
free text keywords: Artemisinin-based combination therapy, Artesunate, Enteric coating, First order drug release, Granulation, Malaria, Mefloquine, Pharmaceutical quality by design, Tableting, Two-drug fixed-dose combination, Artemisinien-gebaseerde kombinasieterapie, Artesunaat, Enteriese bedekking, Eerste orde geneesmiddelvrystelling, Farmaseutiese kwaliteitsontwerp, Granulering, Meflokien, Tablettering, Vastedosiskombinasieproduk
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