publication . Thesis . 2010

Molecular characterisation of a recombinant bovine glycine N-acyltransferase / Christoffel Petrus Stephanus Badenhorst

Badenhorst, Christoffel Petrus Stephanus;
Open Access English
  • Published: 01 Jan 2010
  • Publisher: North-West University
  • Country: Paraguay
Abstract
Conjugation of glycine to organic acids is an important detoxification mechanism. Metabolites of aspirin and industrial solvents, benzoic acid found in plant material and many endogenous metabolites are detoxified by conjugation to glycine. The enzyme responsible for glycine conjugation, glycine N-acyltransferase (GL YAT), is investigated in this study. The enzyme is also important for the management of organic acidemias which are inherited metabolic diseases. However, not all organic acids can be efficiently detoxified by GL YAT. Consequently, some organic acidemias, such as propionic acidemia, are difficult to treat. We hypothesise that a novel variant of GL Y...
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