publication . Doctoral thesis . 2015

The evolution of gene expression in primates

Tashakkori Ghanbarian, Avazeh;
Restricted English
  • Published: 29 May 2015
  • Country: United Kingdom
Abstract
The evolution of a gene’s expression profile is commonly assumed to be independent of its genomic neighborhood. This is, however, in contrast to what we know about the lack of autonomy between expression of neighboring genes in extant taxa. Indeed, in all eukaryotic genomes, genes of similar expression-profile tend to cluster, reflecting chromatin level dynamics. Does it follow that if a gene increases expression in a particular lineage then the genomic neighbors will also increase in their expression or is gene expression evolution autonomous? To address this, I consider evolution of human gene expression since the human-chimp common ancestor, allowing for both...
Subjects
free text keywords: EVOLUTION, Gene Expression, Primates, transposable element, ncRNA, yeast
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