publication . Doctoral thesis . 2015

Electrostatic Properties of Particles for Inhalation

Rowland, Martin;
Restricted English
  • Published: 01 Jan 2015
  • Country: United Kingdom
Abstract
Dry powder inhalers (DPIs) and pressurised metered dose inhalers (pMDIs) are<br/>devices used to deliver therapeutic agents to the lungs. Typically, inhaled active<br/>pharmaceutical ingredients (APIs) are electrically resistive materials and are prone to<br/>accumulating electrostatic charge. The build-up of charge on inhaled therapeutics has<br/>traditionally been viewed as a nuisance as it may result in problems such as weighing<br/>errors, agglomeration, adhesion to surfaces and poor flow. Energetic processing steps<br/>such as micronisation, blending, blister/capsule filling as well as fluidisation of the dose<br/>will result in a large number of particulat...
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