Nebulized Anti-IL-13 Monoclonal Antibody Fab' Fragment Reduces Allergen-Induced Asthma

Article English OPEN
Hacha, Jonathan ; Tomlinson, K ; Maertens, Ludovic ; Paulissen, Geneviève ; Rocks, Natacha ; Foidart, Jean-Michel ; Noël, Agnès ; Palframan, R ; Guéders, Maud ; Cataldo, Didier (2012)
  • Subject: inhalation | mouse model | Inflammation | pulmonary disease | therapy | : Biochimie, biophysique & biologie moléculaire [Sciences du vivant] | : Biochemistry, biophysics & molecular biology [Life sciences]
    mesheuropmc: respiratory system | respiratory tract diseases

Rationale: Interleukin-13 (IL-13) is a prototypic Th2 cytokine and a central mediator of the complex cascade of events leading to asthmatic phenotype. Indeed, IL-13 plays key roles in IgE synthesis, bronchial hyperresponsiveness, mucus hypersecretion, subepithelial fibr... View more
Share - Bookmark