Nebulized Anti-IL-13 Monoclonal Antibody Fab' Fragment Reduces Allergen-Induced Asthma

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Hacha, Jonathan; Tomlinson, K; Maertens, Ludovic; Paulissen, Geneviève; Rocks, Natacha; Foidart, Jean-Michel; Noël, Agnès; Palframan, R; Guéders, Maud; Cataldo, Didier;
(2012)
  • Subject: inhalation | mouse model | Inflammation | pulmonary disease | therapy | : Biochimie, biophysique & biologie moléculaire [Sciences du vivant] | : Biochemistry, biophysics & molecular biology [Life sciences]
    mesheuropmc: respiratory system | respiratory tract diseases

Rationale: Interleukin-13 (IL-13) is a prototypic Th2 cytokine and a central mediator of the complex cascade of events leading to asthmatic phenotype. Indeed, IL-13 plays key roles in IgE synthesis, bronchial hyperresponsiveness, mucus hypersecretion, subepithelial fibr... View more
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