publication . Article . Other literature type . 2009

Targeting nanoparticles to M cells with non-peptidic ligands for oral vaccination

Fievez, Virginie; Plapied, Laurence; des Rieux, Anne; Pourcelle, Vincent; Freichels, Hélène; Wascotte, Valentine; Vanderhaeghen, Marie-Lyse; Jerôme, Christine; Vanderplasschen, Alain; Marchand-Brynaert, Jacqueline; ...
Open Access
  • Published: 01 Sep 2009 Journal: European Journal of Pharmaceutics and Biopharmaceutics, volume 73, pages 16-24 (issn: 0939-6411, Copyright policy)
  • Publisher: Elsevier BV
  • Country: Belgium
Abstract
The presence of RGD on nanoparticles allows the targeting of β1 integrins at the apical surface of human M cells and the enhancement of an immune response after oral immunization. To check the hypothesis that non-peptidic ligands targeting intestinal M cells or APCs would be more efficient for oral immunization than RGD, novel non-peptidic and peptidic analogs (RGD peptidomimitic (RGDp), LDV derivative (LDVd) and LDV peptidomimetic (LDVp)) as well as mannose were grafted on the PEG chain of PCL–PEG and incorporated in PLGA-based nanoparticles. RGD and RGDp significantly increased the transport of nanoparticles across an in vitro model of human M cells as compare...
Subjects
free text keywords: biomaterial, nanomedicine, organic nanoparticle, : Chemistry [Physical, chemical, mathematical & earth Sciences], : Chimie [Physique, chimie, mathématiques & sciences de la terre], : Materials science & engineering [Engineering, computing & technology], : Science des matériaux & ingénierie [Ingénierie, informatique & technologie], Biotechnology, Pharmaceutical Science, General Medicine, Microfold cell, Chemistry, Mannose, chemistry.chemical_compound, Immune system, In vitro, Molecular biology, PEG ratio, Chromatography, Integrin, biology.protein, biology, Antibody, PLGA, Immunology
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publication . Article . Other literature type . 2009

Targeting nanoparticles to M cells with non-peptidic ligands for oral vaccination

Fievez, Virginie; Plapied, Laurence; des Rieux, Anne; Pourcelle, Vincent; Freichels, Hélène; Wascotte, Valentine; Vanderhaeghen, Marie-Lyse; Jerôme, Christine; Vanderplasschen, Alain; Marchand-Brynaert, Jacqueline; ...