Targeting nanoparticles to M cells with non-peptidic ligands for oral vaccination

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Fievez, Virginie; Plapied, Laurence; des Rieux, Anne; Pourcelle, Vincent; Freichels, Hélène; Wascotte, Valentine; Vanderhaegen, Marie-Lyse; Jérôme, Christine; Vanderplasschen, Alain; Marchand-Brynaert, Jacqueline; Préat, Véronique;
  • Subject: biomaterial | nanomedicine | organic nanoparticle | : Chemistry [Physical, chemical, mathematical & earth Sciences] | : Chimie [Physique, chimie, mathématiques & sciences de la terre] | : Materials science & engineering [Engineering, computing & technology] | : Science des matériaux & ingénierie [Ingénierie, informatique & technologie]

The presence of RGD on nanoparticles allows the targeting of β1 integrins at the apical surface of human M cells and the enhancement of an immune response after oral immunization. To check the hypothesis that non-peptidic ligands targeting intestinal M cells or APCs wou... View more
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