publication . Article . Other literature type . 2016

screening for gpr101 defects in pediatric pituitary corticotropinomas

Trivellin G; Rr, Correa; Batsis M; Fr, Faucz; Chittiboina P; Bjelobaba I; Do, Larco; Quezado M; Adrian Daly; Ss, Stojilkovic; ...
Open Access
  • Published: 01 Jun 2016 Journal: Endocrine-Related Cancer, volume 23, pages 357-365 (issn: 1351-0088, eissn: 1479-6821, Copyright policy)
  • Publisher: Bioscientifica
  • Country: Belgium
Abstract
<jats:p>Cushing’s disease (CD) in children is caused by adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas. Germline or somatic mutations in genes such as <jats:italic>MEN1</jats:italic>, <jats:italic>CDKIs</jats:italic>, <jats:italic>AIP</jats:italic>, and<jats:italic> USP8</jats:italic> have been identified in pediatric CD, but the genetic defects in a significant percentage of cases are still unknown. In this study, we investigated the orphan G-protein-coupled receptor <jats:italic>GPR101</jats:italic>, a gene known to be involved in somatotropinomas, for its possible involvement in corticotropinomas. We performed <jats:italic>GPR101</jats:italic...
Subjects
free text keywords: : Endocrinology, metabolism & nutrition [Human health sciences], : Endocrinologie, métabolisme & nutrition [Sciences de la santé humaine], Biology, Endocrinology, medicine.medical_specialty, medicine, Cushing Disease, Somatic cell, Internal medicine, Receptor, Hormone, Immunostaining, MEN1, Cancer research, Germline, Adrenocorticotropic hormone, Article
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